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Related Experiment Videos

Oxidative stress profiling: part II. Theory, technology, and practice.

Richard G Cutler1, John Plummer, Kajal Chowdhury

  • 1Kronos Science Laboratories, Inc., 2222 East Highland Avenue, Suite 220, Phoenix, AZ 85016. richard.cutler@kronoslaboratory.com

Annals of the New York Academy of Sciences
|January 3, 2006
PubMed
Summary

Oxidative stress status (OSS) links to major diseases. Oxidative stress profiling (OSP) measures OSS and its causes, enabling personalized health optimization and targeted therapies for better patient outcomes.

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Area of Science:

  • Biochemistry
  • Medical Diagnostics
  • Personalized Medicine

Background:

  • Oxidative damage in tissues is linked to serious diseases and aging.
  • Individual oxidative stress status (OSS) correlates with increased risk for cancer, heart disease, diabetes, and Alzheimer's.
  • Accurate measurement of OSS components is crucial for understanding disease association and developing personalized therapies.

Purpose of the Study:

  • To introduce Oxidative Stress Profiling (OSP) as a novel strategy.
  • To enable simultaneous assessment of an individual's OSS and identification of contributing physiological factors.
  • To support accurate diagnosis and personalized therapeutic recommendations.

Main Methods:

  • OSP assesses steady-state levels of oxidative damage in nucleic acids, proteins, and lipids.

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  • Measures protective and defense processes using blood, urine, and breath samples.
  • May incorporate pre- and post-exercise testing (70% VO2) for enhanced sensitivity.

    • Main Results:

    • OSP provides a comprehensive view of an individual's OSS.
    • Identifies key physiological parameters (hormones, lipids, antioxidants, iron) influencing OSS.
    • Facilitates the development of integrated calculated OSS results, such as oxidative stress and antioxidant indices.

    Conclusions:

    • OSP is a valuable tool for personalized health optimization.
    • Enables physicians to make more accurate diagnoses and recommend data-driven therapies.
    • Facilitates monitoring of OSS reduction through follow-up testing.