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Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study
Sophia Frangou1, Michael Lewis, Paul McCrone
1Section of Neurobiology of Psychosis, PO66, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. s.frangou@iop.kcl.ac.uk
Background:
Epidemiological and clinical studies suggest that increased intake of eicosapentaenoic acid (EPA) alleviates unipolar depression.
Aims:
To examine the efficacy of EPA in treating depression in bipolar disorder.
Method:
In a12-week, double-blind study individuals with bipolar depression were randomly assigned to adjunctive treatment with placebo (n=26) or with 1 g/day (n=24) or 2 g/day (n=25) of ethyl-EPA. Primary efficacy was assessed by the Hamilton Rating Scale for Depression (HRSD), with changes in the Young Mania Rating Scale and Clinical Global Impression Scale (CGI) as secondary outcome measures.
Results:
There was no apparent benefit of 2 g over 1 g ethyl-EPA daily. Significant improvement was noted with ethyl-EPA treatment compared with placebo in the HRSD (P=0.04) and the CGI (P=0.004) scores. Both doses were well tolerated.
Conclusions:
Adjunctive ethyl-EPA is an effective and well-tolerated intervention in bipolar depression.
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