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Urinary calcium to creatinin ratio in children

Hadi Sorkhi1, Mahmmod Haji Aahmadi

  • 1Department of Pediatric Nephrology, Babol Medical University, Iran. hadisorkhi@pednephir.org

Indian Journal of Pediatrics
|January 3, 2006
PubMed

Insights

The random urine calcium to creatinine ratio (U Ca/Cr) is a useful screening tool for hypercalciuria in children. This study established normal U Ca/Cr values for healthy Iranian school children aged 7-11 years.

Area of Science:

  • Pediatric Nephrology
  • Clinical Chemistry

Background:

  • 24-hour urine collection for hypercalciuria detection is challenging in pediatric patients.
  • The random urine calcium to creatinine ratio (U Ca/Cr) serves as a practical alternative for screening.
  • Establishing population-specific reference ranges is crucial due to inter-regional variations.

Purpose of the Study:

  • To determine the normal random urine calcium to creatinine ratio (U Ca/Cr) in healthy primary school-aged children in Northern Iran.
  • To provide reference values for U Ca/Cr in this specific demographic.
  • To assess the correlation between U Ca/Cr and age in the studied population.

Main Methods:

  • A cross-sectional study involving 590 healthy school children aged 7-11 years in Northern Iran.
  • Analysis of early morning random urine samples for calcium and creatinine concentrations.
  • Calculation of the U Ca/Cr ratio and statistical analysis to determine mean, 95th percentile, and age correlation.

Main Results:

  • The mean U Ca/Cr ratio was 0.155 ± 0.095, with a 95th percentile of 0.36.
  • A statistically significant negative correlation was observed between age and U Ca/Cr ratio (R=-0.101, P=0.014).
  • These findings provide normative data for U Ca/Cr in the target population.

Conclusions:

  • The random urine calcium to creatinine ratio is a valuable screening method for hypercalciuria in children.
  • Normal U Ca/Cr values were established for healthy 7-11 year old children in Northern Iran.
  • It is recommended to establish geographic-specific reference ranges for U Ca/Cr due to observed variations.

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