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Scandia--a potential biomaterial?

H M T U Herath1, L Di Silvio, J R G Evans

  • 1Department of Materials, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK.

Journal of Materials Science. Materials in Medicine
|January 3, 2006
PubMed
Summary
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Scandium oxide (Sc(2)O(3)) shows promising biocompatibility for medical applications. This ceramic material supports human osteoblast cell viability, adhesion, and proliferation, indicating its potential as a biomaterial.

Area of Science:

  • Biomaterials Science
  • Ceramic Engineering
  • Cell Biology

Background:

  • Biocompatibility is crucial for medical biomaterials.
  • Calcium and titanium compounds are established biocompatible materials.
  • Scandium oxide (Sc(2)O(3)) is explored as a novel ceramic biomaterial.

Purpose of the Study:

  • To evaluate the biocompatibility of scandium oxide (Sc(2)O(3)) surfaces.
  • To assess the effect of Sc(2)O(3) on human osteoblast-like cells (HOS TE 85).

Main Methods:

  • Utilized scanning electron microscopy for cell adhesion analysis.
  • Employed MTT assay for cell metabolic function assessment.
  • Used alamarBlue assay to measure cell proliferation.

Main Results:

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  • Both sintered and abraded Sc(2)O(3) surfaces supported cell adhesion.
  • Sc(2)O(3) significantly increased cell proliferation compared to tissue culture controls.
  • Sc(2)O(3) demonstrated non-toxicity and supported cell viability and growth.

Conclusions:

  • Scandium oxide (Sc(2)O(3)) exhibits favorable biocompatibility characteristics.
  • Sc(2)O(3) is a potential candidate for development into advanced biomaterials.