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Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
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Preparation of bone-implants by coating hydroxyapatite nanoparticles on self-formed titanium dioxide thin-layers on

W P S L Wijesinghe1, M M M G P G Mantilaka1, K G Chathuranga Senarathna1

  • 1Department of Chemistry, Faculty of Science, University of Peradeniya, 20400 Peradeniya, Sri Lanka; Postgraduate Institute of Science, University of Peradeniya, 20400 Peradeniya, Sri Lanka.

Materials Science & Engineering. C, Materials for Biological Applications
|April 5, 2016
PubMed
Summary
This summary is machine-generated.

This study presents a novel, low-cost method for creating hydroxyapatite (HA) coated titanium metal (TiM) bone implants. The process enhances implant stability and biocompatibility, significantly reducing corrosion rates in simulated body fluid.

Keywords:
Atomized spray pyrolysisCorrosionHydroxyapatite coatingsTiO(2) thin layerTitanium metal implants

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Area of Science:

  • Biomaterials Science
  • Materials Engineering
  • Orthopedic Implants

Background:

  • Metallic bone implants require surface modifications for improved biocompatibility and stability.
  • Hydroxyapatite (HA) coating enhances osseointegration and reduces corrosion.
  • Titanium metal (TiM) is a common implant material but can corrode in vivo.

Purpose of the Study:

  • To develop a simple, low-cost technique for preparing biocompatible HA-coated TiM bone implants.
  • To evaluate the corrosion resistance and bioactivity of the developed implants.
  • To assess the non-cytotoxicity of the surface-modified implants.

Main Methods:

  • A novel heat treatment process to grow a self-formed TiO2 thin-layer (SFTL) on TiM.
  • Surfactant-assisted synthesis of HA nanorods.
  • Atomized spray pyrolysis (ASP) to coat HA nanorods onto SFTL.
  • Corrosion testing in simulated body fluid (SBF).
  • In vitro cytotoxicity testing using osteoblast-like (HOS) cells.

Main Results:

  • The heat treatment formed an SFTL, which acted as a binder for HA nanoparticles.
  • Corrosion rates of TiM were significantly reduced by heat treatment and HA coating, with the lowest rate at 700 °C.
  • Surface-modified TiM (SMTiM) and HA-coated SMTiM exhibited high bioactivity.
  • Both SMTiM and HA-coated SMTiM were found to be non-cytotoxic to HOS cells.

Conclusions:

  • A novel, cost-effective method for producing HA-coated TiM bone implants was successfully developed.
  • The developed implants demonstrate enhanced corrosion resistance and high biocompatibility.
  • The process offers economic value for the production of advanced bone-implant materials.