Related Experiment Video
Updated: Aug 13, 2026
07:12
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
Prevalence and risk factors for primary hyperparathyroidism in hyperthyroid patients
Bassam Abboud1, Ghassan Sleilaty, Eid Mansour
1Department of General and Endocrine Surgery, Hotel Dieu de France Hospital, Alfred Naccache Street, Beirut-Lebanon. dbabboud@yahoo.fr
Head & Neck
|January 3, 2006
Summary
The prevalence of primary hyperparathyroidism in hyperthyroid patients is 13.5%, especially in older individuals. This finding suggests investigating hypercalcemia in hyperthyroid patients for co-occurring parathyroid disease.
Area of Science:
- Endocrinology
- Surgical Pathology
Background:
- The co-occurrence of hyperthyroidism and primary hyperparathyroidism is likely underestimated.
- This study investigates the combined prevalence and associated factors of these two endocrine disorders.
Purpose of the Study:
- To determine the prevalence of primary hyperparathyroidism in patients undergoing surgery for hyperthyroidism.
- To identify factors associated with the coexistence of these conditions.
Main Methods:
- Retrospective review of 96 patients undergoing elective hyperthyroidism surgery.
- Patients were categorized based on calcium levels: normocalcemia (n=83) or hypercalcemia with primary hyperparathyroidism (n=13).
- Logistic regression analysis was used to identify risk factors.
Main Results:
- The prevalence of concomitant primary hyperparathyroidism was 13.5%.
- Older age (median 61 vs 43 years) and lower thyroid-stimulating hormone levels were associated with co-occurring primary hyperparathyroidism.
- Age was the only significant independent factor (OR, 1.05; 95% CI, 1.008-1.098).
Conclusions:
- Hypercalcemia in hyperthyroid patients warrants investigation for primary hyperparathyroidism, particularly in older individuals.
- Combined thyroidectomy and parathyroidectomy may be indicated for coexisting diseases.
Related Concept Videos
01:25Hyperthyroidism I: Introduction
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
01:27Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
01:24Graves Disease II: Pathophysiology
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
01:23Hypothyroidism II: Pathophysiology
Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
01:28Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
00:59The Parathyroid Glands
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...