Related Experiment Video
Updated: Jul 15, 2026
14:55
Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization
Published on: September 1, 2018
Treatment with human chorionic gonadotropin for PADAM: a preliminary report
A Tsujimura1, K Matsumiya, T Takao
1Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan. akitsuji@uro.med.osaka-u.ac.jp
Summary
Human chorionic gonadotropin (hCG) effectively treats partial androgen deficiency in aging males (PADAM) by increasing testosterone levels. While improving aging male symptoms, it did not significantly impact erectile function or depression scores.
Area of Science:
- Endocrinology
- Andrology
- Geriatrics
Background:
- Partial androgen deficiency of the aging male (PADAM) affects men over 50.
- PADAM symptoms impact quality of life.
- Treatment options for PADAM are continually being explored.
Purpose of the Study:
- To evaluate the efficacy and safety of human chorionic gonadotropin (hCG) in treating PADAM.
- To assess the impact of hCG on hormonal profiles and PADAM symptoms.
Main Methods:
- Twenty-one male patients over 50 with PADAM were enrolled.
- Patients received hCG treatment for an average of 8 months.
- Hormonal levels and symptom scores (AMS, IIEF-5, SDS) were measured pre- and post-treatment.
Main Results:
- Significant increases in total, free, and bioavailable testosterone were observed.
- Aging Males' Symptoms (AMS) scores significantly decreased post-treatment.
- No significant improvements in erectile function (IIEF-5) or depression (SDS) were noted.
Conclusions:
- Human chorionic gonadotropin (hCG) is a potentially effective treatment for PADAM.
- hCG improves hormonal balance and specific aging male symptoms.
- Further research is needed to explore its effects on erectile function and mood.
