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Updated: Aug 1, 2026
04:29
Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
Improving care for depression in patients with comorbid substance misuse
Katherine E Watkins1, Susan M Paddock, Lily Zhang
1RAND Corporation, Santa Monica, CA 90407-2138, USA.
The American Journal of Psychiatry
|January 5, 2006
Summary
Quality improvement programs effectively treat depression in patients with and without substance misuse. These programs reduce the likelihood of depressive disorders, showing benefits for both groups.
Area of Science:
- Clinical Psychology
- Psychiatry
- Public Health
Background:
- Co-occurring substance misuse is linked to poorer depression treatment outcomes.
- Depression management in substance misusers requires effective interventions.
Purpose of the Study:
- To evaluate the effectiveness of quality improvement programs for depression in substance misusers.
- To determine if comorbidity influences program effectiveness.
Main Methods:
- Group-level randomized controlled trial (Partners in Care).
- Comparison of two quality improvement programs (medication, therapy) against usual care.
- Logistic regression analysis of depression and treatment utilization rates.
Main Results:
- Quality improvement programs improved depression outcomes at 6-12 months for patients with and without substance misuse.
- Increased antidepressant use observed at 6 months in substance misusing group.
- Higher treatment utilization noted in non-substance misusing group.
Conclusions:
- Quality improvement programs are effective in reducing probable depressive disorders.
- Co-occurring substance misuse increases risk for poorer depression outcomes under usual care.
- No significant differential program-by-comorbidity effect found, except for psychotherapy use.
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