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Nocardia cyriacigeorgica septicemia
Sameer Elsayed1, Angela Kealey, Carla S Coffin
1Department of Pathology and Laboratory Medicine, University of Calgary, Alberta, Canada. sameer.elsayed@cls.ab.ca
Journal of Clinical Microbiology
|January 5, 2006
Summary
Two cases of Nocardia cyriacigeorgica septicemia were identified in immunocompromised patients. Rapid diagnosis of this rare bloodstream infection was achieved using 16S rRNA gene sequencing.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Genomic Medicine
Background:
- Nocardia cyriacigeorgica is an opportunistic pathogen.
- Disseminated nocardiosis can occur in severely immunocompromised individuals.
- Septicemia due to Nocardia species is uncommon.
Observation:
- Two patients with profound immunodeficiency presented with disseminated infections.
- Blood cultures were positive for Nocardia cyriacigeorgica in both cases.
- 16S rRNA gene sequencing rapidly identified the causative organism.
Findings:
- This study reports the first confirmed cases of Nocardia cyriacigeorgica septicemia in humans.
- The isolates were identified as Nocardia cyriacigeorgica.
- The infections were disseminated.
Implications:
- 16S rRNA gene sequencing is a valuable tool for rapid identification of Nocardia species in blood cultures.
- Early diagnosis and treatment are crucial for managing Nocardia infections in immunocompromised patients.
- These findings expand the known spectrum of Nocardia cyriacigeorgica infections in humans.