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Updated: Aug 13, 2026

Isotopic Effect in Double Proton Transfer Process of Porphycene Investigated by Enhanced QM/MM Method
Published on: July 19, 2019
Exercises in molecular gymnastics--bending, stretching and twisting porphyrins
1School of Chemistry, Trinity College Dublin, Dublin 2, Ireland. sengem@tcd.ie
Abstract:
The functional versatility of tetrapyrroles as natural cofactors is related to their conformational flexibility where manipulation of the macrocycle conformation allows a fine-tuning of their physicochemical properties. This feature article gives a personal account of the synthesis and solid state structural characterization of highly substituted, non-planar porphyrins. Their conformational analysis identifies sterically strained tetrapyrroles as a versatile class of biomimetic compounds with tailor-made properties.
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