Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Image-based extracorporeal tissue engineering of individualized bone constructs.

Ulrich Meyer1, Andre Büchter, Ariane Hohoff

  • 1Clinic for Maxillofacial and Plastic Facial Surgery, University of Düsseldorf, Germany. ulrich.meyer@med.uni-dusseldorf.de

The International Journal of Oral & Maxillofacial Implants
|January 6, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D-Printed Sinus Lift Training Models as an Educational Tool for Dental Students.

Journal of dental education·2026
Same author

Timing of primary maxillary tooth eruption in preterm compared to term infants: a retrospective longitudinal cohort study.

BMC oral health·2026
Same author

Numerical and Experimental Assessment of Oxygen Distribution in a Perfusion Bioreactor to Mimic the Osteochondral Niche.

Biotechnology and bioengineering·2026
Same author

Probing transcription factor subsets in gene regulatory networks.

Algorithms for molecular biology : AMB·2026
Same author

Long-term changes in overjet in individuals with and without orthodontic treatment : A 30-year cohort study.

Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie·2026
Same author

42° as a reference for modern orthodontic arch forms-a mathematical analysis of the Bonwill and Hawley methods.

Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie·2025

This study shows that custom scaffolds with cultured bone cells can effectively support bone regeneration in animal models. This approach holds promise for future bone reconstructive surgery.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Computer-aided technologies are increasingly used in bone tissue engineering.
  • Individualized scaffolds offer potential for enhanced bone regeneration.
  • Autologous osteoblast-like cells are a promising cell source for bone repair.

Purpose of the Study:

  • To evaluate the efficacy of autologous osteoblast-like cells cultured on individualized scaffolds for bone regeneration in a clinical setting.
  • To test the feasibility of computer-aided design/computer-aided manufacturing (CAD/CAM) for creating patient-specific bone defect scaffolds.
  • To assess the integration and bone formation capacity of cell-seeded scaffolds in vivo.

Main Methods:

  • Mandibular bone defects were created in minipigs.

Related Experiment Videos

  • Scaffolds were designed using CAD/CAM and fabricated from polylactic acid/polyglycolic acid copolymers via rapid prototyping.
  • Autologous osteoblast-like cells were cultured and seeded onto the scaffolds before implantation into the defects.

    • Main Results:

    • Computerized tomographic scans confirmed accurate scaffold fit within the defects.
    • Histologic and immunohistochemical analyses indicated successful bone formation.
    • The implanted cell-seeded scaffolds were well-tolerated, showing no adverse reactions.

    Conclusions:

    • In vitro expanded osteoblast-like cells on resorbable, individualized scaffolds can promote in vivo bone defect repair.
    • Combining computer modeling with tissue engineering is a viable strategy for bone reconstructive surgery.
    • This pilot study supports further investigation into CAD/CAM-based tissue engineering for clinical applications.