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Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
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Matrix metalloproteinase target family landscape: a chemometrical approach to ligand selectivity based on protein

Bernard Pirard1, Hans Matter

  • 1Science and Medical Affairs, Chemical Sciences, Drug Design, Aventis Pharma Deutschland GmbH, a Company of the Sanofi-Aventis Group, D-65926 Frankfurt am Main, Germany. bernard.pirard@novartis.com

Journal of Medicinal Chemistry
|January 6, 2006
PubMed

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Ligand Binding Sites02:40

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Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
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