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Updated: Aug 13, 2026

Colonial Wig Pancreaticojejunostomy
Published on: March 12, 2019
Direct percutaneous endoscopic jejunostomy: outcomes in 307 consecutive attempts
John T Maple1, Bret T Petersen, Todd H Baron
1Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Direct percutaneous endoscopic jejunostomy (DPEJ) is a valuable technique for enteral access, but carries a risk of moderate or severe complications in about 10% of patients. Awareness of these risks is crucial for informed decision-making.
Area of Science:
- Gastroenterology
- Endoscopic Procedures
- Surgical Outcomes
Background:
- Direct percutaneous endoscopic jejunostomy (DPEJ) utilization is growing, yet clinical outcome data remain limited.
- Understanding the efficacy and safety of DPEJ is essential for patient care.
Purpose of the Study:
- To evaluate the indications, success rates, and complication profiles of DPEJ.
- To analyze outcomes in a large cohort of over 300 consecutive DPEJ procedures.
Main Methods:
- A retrospective review of 316 attempted DPEJ placements from 1996 to 2004.
- Data abstraction included demographics, indications, success, complications, and follow-up.
- A standardized scheme was used to classify complication severity.
Main Results:
- 209 of 307 DPEJ attempts (68%) were successful.
- Common indications included distal esophageal cancer, obstruction, gastroparesis, and prior resections.
- 69 patients (22.5%) experienced 81 adverse events, with 14 serious complications (e.g., perforation, volvulus, bleeding).
Conclusions:
- DPEJ offers a surgical alternative for enteral access with a 10% rate of moderate to severe complications.
- The procedure is more reliable than percutaneous gastrostomy with jejunal extension.
- Patients and physicians must weigh the benefits against the inherent risks of DPEJ.
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