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Stability of irritable bowel syndrome using a Rome II-based classification.

R E Williams1, C L Black, H-Y Kim

  • 1Worldwide Epidemiology, Glaxo SmithKline, Research Triangle Park, NC 27709, USA. rachel.e.williams@gsk.com

Alimentary Pharmacology & Therapeutics
|January 6, 2006
PubMed
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Irritable Bowel Syndrome (IBS) diagnosis using symptom criteria is unstable over time. Many individuals no longer meet IBS criteria after two years, highlighting the episodic nature of the condition.

Area of Science:

  • Gastroenterology
  • Clinical Epidemiology

Background:

  • Irritable Bowel Syndrome (IBS) diagnosis relies on symptom-based criteria due to the absence of a biological marker.
  • The Rome II criteria are commonly used for IBS classification.

Purpose of the Study:

  • To assess the stability of self-reported symptoms used for Irritable Bowel Syndrome (IBS) classification based on Rome II criteria.
  • To evaluate how consistently individuals meet IBS diagnostic criteria over a two-year period.

Main Methods:

  • A population-based cohort identified with modified Rome II criteria in 2001 was re-evaluated two years later.
  • Data collection utilized a web-based questionnaire to assess current symptoms and IBS classification.

Main Results:

Related Experiment Videos

  • Only 30% of subjects maintained the same IBS subtype, while 52% no longer met IBS criteria at follow-up.
  • Individuals remaining symptomatic were more likely to have the alternating IBS subtype, higher psychological impairment, and lower quality of life.
  • Absence of pain was a key factor for subjects no longer meeting IBS criteria, though many still reported moderate abdominal pain.

    • Conclusions:

    • Irritable Bowel Syndrome (IBS) is characterized by its episodic nature, with significant fluctuations in symptom presentation over time.
    • Current symptom-based classification systems, including Rome II criteria, have limitations in capturing the dynamic course of IBS.