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Updated: Aug 13, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Melanocytic nevus with atypical dermoscopic features at the site of radiodermatitis
Nicola Arpaia1, Nicoletta Cassano, Gino Antonio Vena
1Second Unit of Dermatology, Dept. of Internal Medicine, Immunology, and Infectious Diseases, Policlinico, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy.
Background:
Radiation therapy can cause acute and chronic damage of the skin.
Objective:
A 71-year-old woman presented with an atrophic and sclerotic plaque at a site previously treated with radiotherapy because of lung cancer. Inside the area affected by chronic radiodermatitis, she reported that a preexisting pigmentary lesion had gradually undergone morphologic changes after radiation therapy.
Materials And Methods:
On dermoscopy, the lesion showed features highly suspicious for malignant melanoma. The lesion was excised and examined histopathologically.
Results:
The histopathologic diagnosis was compound congenital melanocytic nevus associated with prominent dermal sclerosis and epidermal atrophy.
Conclusions:
The existence of melanocytes within an atrophic and fibrotic area is a finding typically associated with recurrent or persistent melanocytic lesions. It is likely that the "pseudomelanoma" features of the lesion observed in our patient might have been secondary to the skin changes induced by radiation therapy.
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