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White matter and behavioral neurology.

Christopher M Filley1

  • 1University of Colorado School of Medicine and Denver Veterans Affairs Medical Center, Denver, Colorado, USA. christopher.filley@uchsc.edu

Annals of the New York Academy of Sciences
|January 6, 2006
PubMed
Summary

White matter, crucial for cognition and emotion, is increasingly recognized for its role in brain disorders. Advanced neuroimaging, like diffusion tensor imaging, helps link white matter damage to behavioral changes.

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Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Higher brain function traditionally focused on gray matter.
  • White matter is increasingly recognized for its significant contribution to cognition and emotion.
  • White matter disorders impact development, aging, and various neurologic and psychiatric conditions.

Purpose of the Study:

  • To highlight the importance of white matter in neurobehavioral syndromes.
  • To emphasize the role of neuroimaging in understanding white matter disorders.
  • To introduce the emerging field of behavioral neurology of white matter.

Main Methods:

  • Review of existing literature on white matter and its disorders.
  • Discussion of neuroimaging techniques, particularly diffusion tensor imaging (DTI).
  • Correlation of clinical observations with neuroimaging findings.

Main Results:

  • White matter neuropathology underlies over 100 disorders.
  • White matter dysfunction can lead to "white matter dementia" and focal neurobehavioral syndromes.
  • Neuroimaging, especially DTI, is vital for identifying white matter tracts and lesions.

Conclusions:

  • Understanding white matter's neurobehavioral aspects is crucial for diagnosis, treatment, and prognosis.
  • Sophisticated neuroimaging combined with clinical observation is key to elucidating white matter's role in brain networks.
  • A behavioral neurology of white matter is emerging to better understand brain-behavior relationships.

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