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Serum adenosine deaminase levels in reactional and non-reactional leprosy
P K Nigam1, P Srivastava, P K Patra
1Department of Dermatology, Pt. J.N.M. Medical College, Raipur--492 001, India. nigam4@indiatimes.com
Indian Journal of Dermatology, Venereology and Leprology
|January 6, 2006
Summary
Serum adenosine deaminase (ADA) levels are elevated in leprosy patients, particularly those with multibacillary leprosy and during reactional phases. This indicates increased immune activity in these leprosy forms.
Area of Science:
- Immunology
- Dermatology
- Biochemistry
Background:
- Serum adenosine deaminase (ADA) levels are altered in diseases affecting lymphocytes and the lymphoreticular system.
- Leprosy, a disease involving these systems, has been associated with changes in ADA levels.
Purpose of the Study:
- To investigate serum ADA levels in patients with reactional and non-reactional leprosy.
- To correlate ADA levels with different forms of leprosy.
Main Methods:
- Studied 80 leprosy patients (60 non-reactional, 20 reactional) and 20 healthy controls.
- Measured serum ADA levels using the Giusti method (1974).
Main Results:
- Serum ADA levels were significantly higher in leprosy patients compared to controls.
- Multibacillary leprosy showed significantly elevated ADA levels.
- Reactional leprosy exhibited further increased serum ADA levels.
Conclusions:
- Significantly elevated serum ADA levels are observed in multibacillary leprosy.
- Serum ADA levels increase further during reactional phases of leprosy.
- Increased lymphoreticular activity during reactional phases may explain the elevated ADA levels.