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Clinicopathologic correlation of stage 2 macular hole
Thomas S Hwang1, David J Wilson, Michael L Klein
1Casey Eye Institute, Oregon Health & Science University, Portland, 97239, USA.
Purpose:
To provide histopathologic correlation of the appearance of a stage 2 macular hole.
Methods:
A 79-year-old woman presented with a recent onset of mildly decreased vision in the right eye. With slit-lamp biomicroscopic examination and fundus photography, she was diagnosed as having a stage 2 macular hole. Her vision remained stable thereafter without intervention for 15 months. She died 6 months after her final follow-up examination. Postmortem histopathologic examination of the right eye was carried out by light microscopy of conventional and immunoperoxidase-stained sections.
Results:
The clinical appearance of a stage 2 macular hole in this patient corresponded with findings of intraretinal splitting, which extended beyond an area of surface retinal defect.
Conclusion:
Surface retinal defects associated with intraretinal splitting are a pathway in the development of a macular hole.
