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Published on: February 16, 2016

Effects of iodinated contrast media on blood and endothelium

Peter Aspelin1, Fulvio Stacul, Henrik S Thomsen

  • 1Division of Radiology, Centre for Surgical sciences, Karolinska Institute/Huddinge University Hospital, Stockholm, Sweden.

European Radiology
|January 6, 2006
PubMed

Insights

Iodinated contrast media can affect blood clotting, with ionic types having a stronger anticoagulant effect. Using low-osmolar media and meticulous technique minimizes thrombotic risks in angiography.

Area of Science:

  • Radiology
  • Hematology
  • Vascular Medicine

Background:

  • Intravascular use of iodinated contrast media (ICM) is common in diagnostic and interventional radiology.
  • Potential thrombotic and hematologic complications associated with ICM necessitate a thorough understanding of their effects.

Purpose of the Study:

  • To evaluate the impact of ICM on blood components and endothelium.
  • To develop clinical guidelines for mitigating thrombotic and hematologic complications from ICM administration.

Main Methods:

  • Comprehensive review of experimental and clinical studies.
  • Literature analysis and expert consensus from the European Society of Urogenital Radiology's Contrast Media Safety Committee.

Main Results:

  • All ICM exhibit anticoagulant properties, more pronounced with ionic agents.
  • Some in vitro/in vivo experimental findings on hematologic effects lack clinical confirmation.
  • Low- or iso-osmolar contrast media are recommended for angiographic procedures.

Conclusions:

  • Meticulous angiographic technique is paramount in preventing thrombotic complications.
  • The use of specific drugs and devices further reduces thromboembolic risks, diminishing the relative impact of ICM effects.

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