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Related Experiment Videos

Diffusion-weighted MR imaging in transient ischaemic attacks.

C Lamy1, C Oppenheim, D Calvet

  • 1Service de Neurologie, de l' Hôpital Sainte-Anne, 1, rue Cabanis, 75674 Paris Cedex 14, France. c.lamy@ch-sainte-anne.fr

European Radiology
|January 6, 2006
PubMed
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Diffusion-weighted imaging (DWI) detects abnormalities in over a third of transient ischemic attack (TIA) patients. Prolonged TIA symptoms, aphasia, and motor deficits predict these DWI lesions.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Transient ischemic attack (TIA) is a critical warning sign for stroke.
  • Diffusion-weighted imaging (DWI) is a sensitive MRI technique for detecting acute ischemic changes.
  • Understanding DWI lesion characteristics in TIA is crucial for diagnosis and risk stratification.

Purpose of the Study:

  • To determine the frequency and characteristics of diffusion-weighted imaging (DWI) abnormalities in patients diagnosed with transient ischemic attack (TIA).
  • To identify predictors of DWI lesions in TIA patients.

Main Methods:

  • Analysis of data from 98 consecutive TIA patients admitted between January 2003 and April 2004.
  • Comparison of clinical characteristics (age, gender, symptoms, delay to MRI) between patients with (DWI+) and without (DWI-) DWI lesions.

Related Experiment Videos

  • Calculation of DWI lesion volume and apparent diffusion coefficient (ADC) values.
  • Use of multiple logistic regression to identify independent predictors of DWI lesions.

    • Main Results:

    • DWI revealed ischemic lesions in 34.7% of TIA patients.
    • Lesions were typically small (mean volume 1.9 cm³), with moderately decreased ADC ratios (mean 79.5%).
    • Independent predictors for DWI lesions included TIA duration ≥ 60 minutes (OR 7.6), aphasia (OR 9.2), and motor deficit (OR 5.1).
    • All DWI+ patients received a probable TIA diagnosis.

    Conclusions:

    • DWI is a valuable tool for detecting ischemic lesions in TIA patients.
    • Prolonged TIA duration, aphasia, and motor deficits are significantly associated with the presence of DWI lesions.
    • Over half of TIA patients with symptoms lasting longer than 60 minutes exhibit DWI lesions, highlighting the importance of prompt neuroimaging.