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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
Promoting children's health through understanding of genetics and genomics
Carole Kenner1, Agatha M Gallo, Kellie D Bryant
1University of Oklahoma Health Sciences Center, College of Nursing, Oklahoma City, OK 73117, USA. Carole-Kenner@ouhsc.edu
Insights
Genetics and genomics offer powerful tools for predicting, treating, and preventing childhood diseases. Understanding genetic profiles alongside environmental factors enables personalized health care and disease prevention strategies for children.
Area of Science:
- Pediatric Health
- Genetics
- Genomics
Background:
- The Human Genome Project provides significant potential for advancing pediatric health care.
- Many childhood conditions arise from complex gene-environment interactions, not just single genes.
Purpose of the Study:
- To explore the impact of genetics and genomics on children's health care.
- To identify common childhood diseases with genetic origins.
Main Methods:
- Literature review to identify childhood diseases linked to genetic causes.
- Selection of case examples demonstrating the application of genetic knowledge in practice.
Main Results:
- Genetic knowledge aids in holistic health promotion and disease prevention for children.
- Two illustrative examples highlight practical applications for health professionals.
Conclusions:
- Integrating genetic profiles with lifestyle and environmental context offers a comprehensive health perspective.
- Clinical implications include personalized treatment options and tailored health promotion based on genetic predispositions and environmental interactions.
Purpose:
To describe the effects of genetics and genomics on children's health care.
Organizing Construct:
The breakthroughs in the Human Genome Project have great potential for disease prediction, treatment, and prevention in the health care of children with chronic health conditions. Most childhood conditions based on a single gene are influenced by a complex interaction of genetic and environmental factors.
Methods:
A review of the literature was conducted to determine the most common childhood diseases linked to genetic causes.
Findings:
Two examples were selected to depict how a health professional would use genetic knowledge to provide holistic health promotion and disease prevention.
Conclusions:
Knowledge of the interaction of the genetic profile coupled with a person's lifestyle, work environment, and family context provide a more holistic picture of a person's health profile. The clinical implications are that this knowledge will provide opportunities for health professionals to advise families on individualized treatment options or to tailor health promotion to future disease states based on genes and their interaction with the environment.
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