Related Experiment Video
Updated: Aug 13, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Induced hypothermia in neurocatastrophes: feeling the chill
1Division of Critical Care Neurology and Neurological-Neurosurgical Intensive Care Unit, Mayo Medical Center, Rochester, MN, USA.
Abstract:
Reducing core temperature to protect the injured brain has become a new therapeutic measure. The scientific underpinnings based on animal experiments seem sound. Evidence of the therapy's effect in human trials is insufficient or even possibly absent, but the techniques to produce moderate hypothermia are available, without apparent significant complications, and are relatively easy to use for neurointensivists. This review summarizes the mechanisms of neuroprotection due to hypothermia and its application in clinical practice.
Related Concept Videos
Thermosensation
Decreased Body Temperature
Homeostatic Imbalances in Body Temperature
Cytotoxic Edema: Pathophysiology
Body Temperature
Body Temperature
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C (97–99°F), remaining relatively stable...

