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Updated: Aug 13, 2026

Murine Model of Central Venous Stenosis using Aortocaval Fistula with an Outflow Stenosis
Published on: July 11, 2019
[Vascular access for hemodialysis in patients with central vein stenosis or obstruction]
Eric S Chemla1, Benedetta Zappa, Alessandro Costanzo
1Department of Renal Surgery and Transplantation, St George's Hospital, London.
Insights
Complex hemodialysis access procedures using saphenous veins and PTFE grafts offer a viable solution for patients with central vein stenosis or obstruction, enabling line-free dialysis in 70% of cases.
Area of Science:
- Vascular Surgery
- Nephrology
- Interventional Radiology
Context:
- Central vein stenosis or obstruction significantly limits hemodialysis access options.
- Patients with these conditions often have contraindications for peritoneal dialysis.
- This study addresses the challenges of creating effective vascular access in this complex patient group.
Purpose:
- To report the experience with complex hemodialysis access procedures in patients with central vein stenosis or obstruction.
- To evaluate the patency and usability of various surgical techniques, including saphenous vein grafts and PTFE bypasses.
- To propose management guidelines for such challenging cases.
Summary:
- Twelve procedures were performed on 10 patients using saphenous veins (loops and transpositions) and PTFE grafts (axillary-popliteal and brachial-jugular).
- Outcomes varied, with some grafts and fistulae achieving long-term patency and regular use for dialysis.
- Despite complications like clotting and steal syndrome, 70% of patients achieved line-free dialysis.
Impact:
- Demonstrates the feasibility of achieving successful hemodialysis access in patients with severe central vein stenosis or obstruction.
- Highlights the potential of various surgical interventions to improve patient outcomes and quality of life.
- Provides insights for surgical and radiological management strategies in complex vascular access cases.
Abstract:
The aim of our study was to report our experience with complex haemodialysis access procedures for patients presenting central vein stenosis or obstruction. Between September 2002 and December 2003 we performed 12 procedures on 10 patients presenting central vein stenosis or obstruction; all of them presented contraindications to peritoneal dialysis. Saphenous veins were used 6 times, twice as loops to the femoral artery and 4 times as transpositions to the popliteal artery above the knee; 3 axillary artery to popliteal vein PTFE bypasses; and 1 brachial artery to internal jugular vein PTFE graft. The PTFE graft to the jugular vein has been patent and regularly needled with a follow-up of 4 months. Four saphenous vein fistulae were regularly used for dialysis; 2 were never needled. Five saphenous fistulae clotted after an average life span of 4 months (range: 3 weeks-9 months) and one is still patent and in use (5 months). Both femoral vein transpositions have been patent and have been needled 3 times a week with a follow-up of 10 and 4 months; one had to be revised surgically after 9 months. Of the 3 axillary artery to popliteal vein grafts, one had to be closed after a week because of severe steal syndrome and 2 have been patent (1 year and 8 month follow-up) and have been needled regularly ever since. Seventy percent of these patients has been dialysed line free through their fistula despite severe central vein stenosis or obstruction. Although the follow-up needs to be longer we discuss the surgical, radiological and dialysis features of these patients and propose management guidelines for cases of central vein stenosis or occlusion.
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