[Structural and functional response of lymph node to sciatic nerve compression in combination with lymphotropic...

Morpho-functional state of lymph node (LN) after the sciatic nerve compression was studied experimentally in rats and the application of lymphotropic drugs was substantiated. Sciatic nerve compression resulted in the changes of the relative area, occupied by structures of LN and in formation of definite cortico-medullary ratio. With the increase of duration of postcompression period, the stable augmentation of the dimensions of a thymus-dependent zone was found in combination with the prevalence of a thymus-independent zone, which is indicative of the mixed variant of immune response to sciatic nerve compression. Application of lymphotropic drugs (lymphotropic injections, "Phytopan" biologically active additive) was shown to change LN structural response to sciatic nerve compression. The degree of response of various structures of a denervated LN, found in rats receiving the drugs, was different as compared with that one in untreated animals, and was characterized by an inverse mode of reaction of LN T- and B-dependent zones. The results obtained emphasize the necessity of taking into account the state of LN in pathology of peripheral nervous system.