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Enalapril influence on blood pressure and echocardiographic parameters in children with acute postinfectious

Augustina Jankauskiene1, Vilija Cerniauskiene, Marija Jakutovic

  • 1Vilnius University Children's Hospital, Vilnius, Lithuania. augustinaj@delfi.lt

Medicina (Kaunas, Lithuania)
|January 13, 2006
PubMed

Insights

Early enalapril treatment in children with acute postinfectious glomerulonephritis improved blood pressure and cardiac function. While initial benefits were observed, long-term outcomes require further investigation.

Area of Science:

  • Pediatric Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Acute postinfectious glomerulonephritis (APIGN) is a common kidney disease in children.
  • Hypertension and cardiac dysfunction can be complications of APIGN.
  • Angiotensin-converting enzyme (ACE) inhibitors are used to manage hypertension.

Purpose of the Study:

  • To assess the impact of early enalapril treatment on blood pressure and cardiac parameters in children with APIGN.
  • To evaluate the efficacy and safety of enalapril in this pediatric population.

Main Methods:

  • A cohort of 51 children with APIGN was studied.
  • 26 children received enalapril for 6 weeks; 25 served as controls.
  • Blood pressure was monitored regularly; echocardiography was performed at baseline and after 6-8 weeks.

Main Results:

  • Enalapril-treated children showed an earlier reduction in blood pressure compared to controls.
  • Significant improvements were observed in left ventricular diameters, mass, and mitral peak flow velocity in the enalapril group.
  • Echocardiographic parameters remained unchanged in the untreated group.

Conclusions:

  • Early enalapril administration in children with APIGN demonstrates a beneficial antihypertensive effect and improves cardiac function.
  • Further research is needed to determine if these early improvements influence the long-term prognosis of APIGN.
Abstract

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