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Drugs for asthma.

Peter J Barnes1

  • 1Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, SW3 6LY London. p.j.barnes@imperial.ac.uk

British Journal of Pharmacology
|January 13, 2006
PubMed
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Pharmacology has significantly advanced asthma drug development, evolving natural compounds into effective treatments like beta(2)-adrenoceptor agonists and corticosteroids. While current therapies are successful, discovering novel asthma treatments remains a challenge for pharmacology.

Area of Science:

  • Pharmacology and Pharmaceutical Sciences
  • Respiratory Medicine
  • Drug Discovery

Background:

  • Asthma management has progressed significantly due to pharmaceutical developments rooted in natural products.
  • Understanding drug mechanisms has elucidated key asthma pathophysiology.

Observation:

  • Beta(2)-adrenoceptor agonists and corticosteroids, derived from adrenal gland substances, are highly effective bronchodilators and anti-inflammatory agents, respectively.
  • Combination inhalers of long-acting beta(2)-agonists and corticosteroids represent the current gold standard in asthma therapy.
  • The molecular mechanisms of cromoglycate and theophylline, while used in asthma therapy, are not fully understood.

Findings:

  • Pharmacology has successfully refined natural products into safe and effective long-term asthma therapies.

Related Experiment Videos

  • The development of novel asthma therapies has been challenging, with leukotriene antagonists being less effective than existing treatments.
  • Targeted therapies like cytokine inhibitors are less effective than corticosteroids, and more potent treatments carry unacceptable side effect risks.

    • Implications:

    • Pharmacology remains the primary discipline for advancing asthma treatment, despite challenges in discovering new drug classes.
    • Future improvements in asthma therapy are likely to stem from further pharmacological innovations rather than solely from molecular genetics.
    • Continued research into drug mechanisms is crucial for optimizing existing asthma treatments and developing new ones.