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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Related Experiment Video

Updated: Dec 11, 2025

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
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Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach.

Yosuke Fukuda1, Kaho Akimoto1, Tetsuya Homma1

  • 1Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, 1-5-8 Shinagawa-ku, Tokyo 142-8555, Japan.

Journal of Clinical Medicine
|August 23, 2020
PubMed
Summary
This summary is machine-generated.

Cellular senescence, particularly involving SIRT1, plays a role in asthma exacerbations. Targeting SIRT1 may offer a new strategy for treating virus-induced asthma attacks.

Keywords:
SIRT1asthmacellular senescenceexacerbationsvirus infection

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Area of Science:

  • Pulmonology
  • Immunology
  • Cellular Biology

Background:

  • Asthma prevalence is rising globally, with viral infections frequently triggering exacerbations.
  • These exacerbations cause significant airway inflammation, reduced quality of life, and increased healthcare utilization.
  • Current treatments for virus-induced asthma exacerbations are insufficient.

Purpose of the Study:

  • To review the role of Silent Information Regulator 2 homolog sirtuin 1 (SIRT1) in bronchial asthma pathogenesis.
  • To examine SIRT1's involvement in inflammatory cells during virus-induced asthma exacerbations.
  • To explore SIRT1 as a potential therapeutic target for asthma.

Main Methods:

  • Literature review focusing on cellular senescence and SIRT1 in asthma.
  • Analysis of studies investigating SIRT1's role in inflammatory pathways.
  • Examination of models linking viral infections and SIRT1 levels.

Main Results:

  • SIRT1 is implicated in the pathology of both stable and exacerbated asthma.
  • Decreased SIRT1 levels are observed in various asthma endotypes and phenotypes.
  • SIRT1 is linked to cellular senescence and inflammatory responses in virus-induced exacerbations.

Conclusions:

  • SIRT1 is a key factor in the pathogenesis of bronchial asthma.
  • Targeting SIRT1 presents a promising novel therapeutic strategy for managing virus-induced asthma exacerbations.