Related Experiment Videos
Endoneurial capillary abnormalities in mild human diabetic neuropathy
R A Malik1, A Veves, E A Masson
1Department of Anatomy, Aberdeen Royal Infirmary.
Journal of Neurology, Neurosurgery, and Psychiatry
|July 1, 1992
Summary
Diabetic neuropathy involves microvascular changes. Studies show reduced endoneurial capillary density and increased basement membrane area in patients, linking microvascular disease to nerve damage severity.
Area of Science:
- Neurology
- Pathology
- Diabetology
Background:
- Diabetic neuropathy is a common complication of diabetes mellitus.
- Microvascular factors are suspected in its pathogenesis.
Purpose of the Study:
- To assess microangiopathy extent in diabetic neuropathy patients.
- To correlate microvascular changes with neuropathic severity.
Main Methods:
- Compared endoneurial capillary density in 15 diabetic patients with mild neuropathy and 8 controls.
- Analyzed basement membrane area and endothelial cell profiles.
- Assessed neurophysiological and neuropathological measures.
Main Results:
- Reduced endoneurial capillary density correlated with lower myelinated fibre density.
- Increased basement membrane area and endothelial cell number per capillary linked to neuropathic severity.
- No evidence of endothelial cell hypertrophy or altered closed vessel percentage.
Conclusions:
- Microvascular abnormalities are prominent in mild diabetic neuropathy.
- Endoneurial capillary disease plays a role in diabetic neuropathy development.