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Published on: February 26, 2013
Peripheral Artery Disease and Atrial Fibrillation: A Systematic Review and Meta-analysis on 763,919 Patients
Daniele Pastori1, Danilo Menichelli2, Gianluca Gazzaniga2
1Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy; IRCCS Neuromed, Località Camerelle, Pozzilli, Italy.
JACC. Advances
|August 7, 2026
Summary
Peripheral artery disease (PAD) is linked to a 34% increased risk of new-onset atrial fibrillation (NOAF). Managing atherosclerotic risk factors in PAD patients may help lower NOAF risk.
Area of Science:
- Cardiology
- Vascular Medicine
- Epidemiology
Background:
- Cardiovascular risk factors are linked to new-onset atrial fibrillation (NOAF).
- The association between peripheral artery disease (PAD) and NOAF requires further investigation.
Purpose of the Study:
- To estimate the risk of NOAF in patients with PAD.
Main Methods:
- Systematic review and meta-analysis of observational studies.
- Searched MEDLINE (PubMed) and EMBASE databases.
- Stratified results based on ankle-brachial index (ABI) values.
Main Results:
- Included 7 studies with over 763,000 patients.
- PAD was associated with an increased risk of NOAF (HR: 1.34).
- Clinically overt PAD showed the strongest association with NOAF.
Conclusions:
- Observational data suggest PAD is associated with a 34% increased risk of NOAF.
- Proactive management of atherosclerotic risk factors in PAD patients may reduce NOAF risk.
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