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Real-time imaging of regional myocardial function using fast-SENC
Li Pan1, Matthias Stuber, Dara L Kraitchman
1Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA.
Magnetic Resonance in Medicine
|January 13, 2006
Summary
Fast strain-encoded (SENC) magnetic resonance imaging (MRI) enables rapid assessment of regional myocardial function within a single heartbeat. This advanced technique accurately measures ventricular contraction, proving valuable for stress or arrhythmia imaging.
Area of Science:
- Cardiovascular Imaging
- Magnetic Resonance Imaging
- Myocardial Mechanics
Background:
- Assessing regional myocardial function is crucial for diagnosing cardiac conditions.
- Conventional strain-encoded (SENC) magnetic resonance imaging (MRI) requires long acquisition times, limiting its clinical utility, especially during dynamic physiological states like stress or arrhythmia.
- Faster imaging techniques are needed to overcome these limitations.
Purpose of the Study:
- To present and validate a novel fast SENC (fast-SENC) technique for rapid imaging of regional myocardial function.
- To enable cardiac function assessment within a single heartbeat.
- To evaluate the feasibility of fast-SENC in human subjects and animal models.
Main Methods:
- Developed fast-SENC by combining spiral acquisition with SENC MRI.
- Implemented localized SENC with a reduced field of view (FOV) to prevent foldover artifacts.
- Acquired low- and high-tuning SENC images in an interleaved manner throughout the cardiac cycle.
- Assessed regional circumferential and longitudinal strain in the left and right ventricles using long- and short-axis views.
Main Results:
- Achieved scan durations as short as a single heartbeat.
- Demonstrated comparable results to conventional SENC imaging despite significantly reduced acquisition time.
- Successfully imaged regional myocardial function in both human subjects and infarcted dogs.
- Localized SENC effectively minimized foldover artifacts.
Conclusions:
- Fast-SENC is a viable technique for rapid, single-heartbeat imaging of regional myocardial function.
- The method accurately quantifies ventricular contraction (circumferential and longitudinal strain).
- Fast-SENC holds significant potential for clinical applications requiring rapid imaging, such as during cardiac stress tests or in patients with arrhythmias.