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Does a gender difference in response to cardiac resynchronization therapy exist?

Gabe B Bleeker1, Martin J Schalij, Eric Boersma

  • 1Department of Cardiology, Leiden University Medical Center, The Netherlands.

Pacing and Clinical Electrophysiology : PACE
|January 13, 2006
PubMed

Insights

Cardiac resynchronization therapy (CRT) benefits heart failure patients. This study found no significant gender differences in CRT response or long-term survival rates for men and women.

Area of Science:

  • Cardiology
  • Heart Failure Management
  • Medical Device Therapy

Background:

  • Cardiac resynchronization therapy (CRT) improves symptoms, exercise capacity, and left ventricular (LV) function in heart failure patients.
  • Previous research suggests potential gender-specific responses to medical interventions, necessitating investigation in CRT outcomes.

Purpose of the Study:

  • To investigate potential gender-based differences in the efficacy and long-term outcomes of cardiac resynchronization therapy (CRT).

Main Methods:

  • A cohort of 173 patients (137 men, 36 women) with advanced heart failure (NYHA class III-IV, LVEF ≤35%, QRS >120 ms) received CRT.
  • Clinical and echocardiographic parameters were assessed at baseline and 6 months post-CRT, with follow-up extending up to 5 years.
  • Outcomes, including response rates and survival, were compared between male and female patients.

Main Results:

  • Overall, CRT significantly improved clinical and echocardiographic parameters in all patients at 6 months.
  • No significant differences were observed in the magnitude of improvement in NYHA class or LV ejection fraction (LVEF) between women and men.
  • Response rates (76% women vs. 80% men) and 2-year survival (84% women vs. 80% men) were comparable between genders.

Conclusions:

  • Cardiac resynchronization therapy (CRT) demonstrates similar efficacy and long-term survival benefits for both men and women with advanced heart failure.
  • Gender does not appear to be a significant factor influencing the response to CRT or patient outcomes.
Abstract

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