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Updated: Aug 13, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Strategies for the treatment of acute promyelocytic leukemia
Olga Frankfurt1, Martin S Tallman
1Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Care Center of Northwestern University, 676 North St. Clair Street, Suite 850, Chicago, IL 60611, USA. o-frankfurt@northwestern.edu
Abstract:
The outcome of acute promyelocytic leukemia (APL) has improved dramatically during the past 40 years. Insights into the genetic and biologic mechanisms of APL lead to the development of specific and effective therapeutic strategies. This article discusses the therapeutic interventions that transformed APL from one of the most lethal leukemias to one that is highly curable.
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