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Localized internal radiotherapy with 90Y particles embedded in a new thermosetting alginate gel: a feasibility study
Oyvind Holte1, Arne Skretting, Tore Bach-Gansmo
1School of Pharmacy, University of Oslo, Norway. oholte@farmasi.uio.no
Background:
Internal radiotherapy requires the localization of the radionuclide to the site of action. A new injectable alginate gel formulation intended to undergo immediate gelation in tissues and capable of encapsulating radioactive particles containing 90Y was investigated.
Methods:
The formulation was injected intramuscularly, into the bone marrow compartment of the femur and intravenously, respectively, in pigs. The distribution of radioactivity in various tissues was determined.
Results:
Following intramuscular injection, more than 90% of the radioactivity was found at the site of injection. Following injection into bone marrow, 30-40% of the radioactivity was retained at the site of injection, but a considerable amount of radioactivity was also detected in the lungs (35-45%) and the liver (5-18%). Following intravenous injection, 80-90% of the radioactivity was found in the lungs.
Conclusion:
The present formulation appears suitable for localized radiotherapy in organs and tissues having low perfusion.
