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Updated: Jul 27, 2026
11:27
Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging
Published on: April 4, 2013
Summary
This review covers myelography contrast media history. Newer water-soluble agents like Metrizamide (Amipaque) show fewer adverse reactions compared to older, non-absorbable or less accepted options.
Area of Science:
- Radiology
- Medical Imaging
- Neurology
Background:
- Myelography utilizes contrast media for spinal canal imaging.
- Historical contrast agents have varied absorption and side effect profiles.
- Adverse reactions to contrast media have driven the development of safer alternatives.
Purpose of the Study:
- To review the historical evolution of contrast media used in myelography.
- To compare the safety and efficacy of different myelographic contrast agents.
- To highlight the development and benefits of newer contrast media.
Main Methods:
- Literature review of historical and current myelographic contrast agents.
- Analysis of reported side effects and absorption characteristics.
- Comparison of reaction rates between different contrast media types.
Main Results:
- Air is safely absorbed; Lipiodol and Pantopaque cause arachnoiditis due to non-absorption.
- Diodrast and Thorotrast had limited acceptance; Dimer-X and Conray 60 cause reactions.
- Metrizamide (Amipaque), a new nonionic water-soluble agent, demonstrates fewer adverse reactions.
Conclusions:
- Contrast media for myelography have evolved significantly over time.
- Nonionic water-soluble agents like Metrizamide represent an advancement in patient safety.
- Metrizamide offers a favorable safety profile compared to previous myelographic contrast agents.
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