[Diagnosis of anaplastic large-cell lymphoma]

Principles of morphological diagnosis of anaplastic large-cell lymphoma (ALCL) are considered, several its variants are distinguished: classic (32 cases), small-cell (4 cases), rich in granulocytes (2 cases) and lymphohistiocytic (1 case). ALK expression was variable: 93% at the age up to 20, 60% at the age from 20 to 40 years, none at the age 40 years and older. Morphological similarities between ALCL, classic variants of Hodgkin's lymphoma, variants of diffuse large B-cell lymphoma may require immunohistochemical investigation the criteria of which are suggested.