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Related Experiment Videos

Biodegradable pericardial implants for bladder augmentation: a 2.5-year study in dogs.

H Kambic1, R Kay, J F Chen

  • 1Department of Biomedical Engineering, Cleveland Clinic Foundation, Ohio.

The Journal of Urology
|August 1, 1992
PubMed
Summary

Biodegradable pericardial tissue grafts effectively augment canine bladders, creating a functional reservoir for urine. This innovative approach allows for bladder enlargement and regeneration over time.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Urology

Background:

  • Bladder augmentation is crucial for treating conditions causing bladder dysfunction.
  • Existing augmentation methods have limitations, necessitating novel biomaterials.
  • Biodegradable materials offer potential for tissue regeneration and gradual replacement.

Purpose of the Study:

  • To evaluate the efficacy of biodegradable pericardial tissue grafts for canine bladder augmentation.
  • To assess the structural integrity, functional capacity, and regenerative potential of the augmented bladders.
  • To determine the long-term outcomes of using chemically treated pericardial grafts stored in ethanol.

Main Methods:

  • Canine partial cystectomy (50%) followed by augmentation with a 2-layer sutured pericardial graft.

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  • Graft preparation involved acetic acid/anhydride treatment and 18-27 months of ethanol storage.
  • Control groups included primary closure and augmentation with non-stored fresh tissue.
  • Assessment via excretory urography, cystography, urodynamics, and postmortem histology up to 36 months.

    • Main Results:

    • Achieved adequate bladder capacity and function, confirmed by urodynamics up to 36 months.
    • No operative complications were observed.
    • Histology showed a smooth, epithelialized inner surface with no irregularities or suture lines.
    • The graft served as a template for epithelial regeneration and was progressively reabsorbed.

    Conclusions:

    • Ethanol-stored, acetylated pericardial tissue is a viable biomaterial for bladder augmentation.
    • The grafts provide a structural reservoir and promote epithelial regeneration.
    • This technique allows for volumetric bladder enlargement with gradual graft resorption.