Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Orbitofrontal cortex, decision-making and drug addiction.

Geoffrey Schoenbaum1, Matthew R Roesch, Thomas A Stalnaker

  • 1Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, HSF-2 S251, Baltimore, MD 21201, USA. schoenbg@schoenbaumlab.org

Trends in Neurosciences
|January 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The oracle and the didact: Orbitofrontal influences on learning and dopaminergic error signaling.

Neuron·2026
Same author

Prior cocaine use disrupts identification of hidden states by single units and neural ensembles in orbitofrontal cortex.

eLife·2026
Same author

Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema.

Nature communications·2026
Same author

A "personality test" for rats reveals subtle but distinct effects of sex and early life inflammation on brain and behavior.

Behavioral neuroscience·2026
Same author

Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia.

Scientific reports·2025
Same author

Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior.

bioRxiv : the preprint server for biology·2025
Same journal

Building neuroscience capacity in low- and middle-income countries: Lessons from Ghana.

Trends in neurosciences·2026
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
See all related articles

The orbitofrontal cortex (OFC) uses associative learning to guide future decisions. Disruptions in OFC circuits due to drug use may cause maladaptive decision-making in addiction.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Decision-Making Research

Background:

  • The orbitofrontal cortex (OFC), a prefrontal cortex region, is vital for executive function.
  • The OFC possesses unique connections with subcortical structures like the basolateral amygdala and nucleus accumbens, crucial for associative learning.

Purpose of the Study:

  • To review evidence supporting the OFC's role in using associative information for future projection and decision-making.
  • To examine how drug-induced alterations in OFC circuits contribute to maladaptive decision-making in addiction.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of neurobiological evidence linking OFC function to decision-making.
  • Examination of drug addiction models and their impact on brain circuits.

Related Experiment Videos

Main Results:

  • The OFC integrates associative learning with value-based decision-making.
  • Specific brain circuit alterations caused by drugs disrupt the OFC's predictive signaling.
  • Loss of OFC function is associated with impaired decision-making in addiction.

Conclusions:

  • The OFC's unique connectivity enables it to guide decisions based on expected outcomes.
  • Dysfunctional OFC circuits, often drug-induced, are a key factor in the decision-making deficits seen in addiction.