Related Experiment Video
Updated: Aug 13, 2026
09:15
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Lipid lowering activity of Eclipta prostrata in experimental hyperlipidemia
C Santhosh Kumari1, S Govindasamy, E Sukumar
1Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India.
Journal of Ethnopharmacology
|January 13, 2006
Summary
Eclipta prostrata, used in Indian traditional medicine, shows promising antihyperlipidemic effects. Studies in rats confirm its potential to manage high cholesterol levels, supporting its medicinal use.
Area of Science:
- Phytochemistry
- Pharmacology
- Traditional Medicine
Background:
- Eclipta prostrata is traditionally used in India for hepatic diseases and hyperlipidemia.
- Hyperlipidemia is a significant risk factor for cardiovascular diseases.
Purpose of the Study:
- To investigate the antihyperlipidemic potential of Eclipta prostrata.
- To scientifically validate the traditional use of the plant in managing hyperlipidemia.
Main Methods:
- The total alcoholic extract of Eclipta prostrata was administered to albino rats.
- Lipid profiles of serum, liver, and heart were analyzed in control and treated groups.
- Activity was compared against standard antihyperlipidemic drugs.
Main Results:
- The Eclipta prostrata extract demonstrated a dose-dependent antihyperlipidemic activity.
- Significant alterations in lipid profiles were observed in treated animals compared to controls.
- The plant extract showed comparable activity to standard drugs.
Conclusions:
- The findings support the traditional medicinal use of Eclipta prostrata for hyperlipidemia.
- Eclipta prostrata possesses significant antihyperlipidemic properties.
- Further research into the active compounds and mechanisms of action is warranted.
Related Concept Videos
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
01:18Lipids: Dietary Sources and Requirements
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...