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Updated: Aug 13, 2026
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
Clinical ability of pattern electroretinograms and visual evoked potentials in detecting visual dysfunction in ocular
Vincenzo Parisi1, Stefano Miglior, Gianluca Manni
1Fondazione per l'Oftalmologia G. B. Bietti-IRCCS, Rome, Italy. vparisi@tin.it
Objective:
To assess the presence of normal or abnormal pattern electroretinogram (PERG) and visual evoked potential (VEP) responses in patients with ocular hypertension or open-angle glaucoma (OAG).
Design:
Retrospective, cross-sectional, case-control study.
Participants:
Eighty normal control subjects (mean age, 51.77+/-6.04 years; 80 eyes), 68 ocular hypertension patients (mean age, 51.58+/-7.12; 68 eyes; intraocular pressure [IOP] < 18 mmHg under pharmacological treatment; Humphrey field analysis [HFA] 24/2 mean deviation [MD] > -2 decibels [dB]), and 84 OAG patients (mean age, 52.77+/-5.28; 84 eyes; IOP < 18 mmHg under pharmacological treatment; HFA 24/2 mean deviation between -2 and -23 dB) were enrolled.
Methods:
Simultaneous recording of PERGs and VEPs using high-contrast (80%) 15' checkerboard stimuli reversed at the rate of 2 reversals per second.
Main Outcome Measures:
Pattern electroretinogram P50 and VEP P100 implicit times were considered delayed when exceeding the limit of mean values of controls plus 2 standard deviations (SDs). Pattern electroretinogram P50 to N95 and VEP N75 to P100 amplitudes were considered reduced when exceeding the limit of mean values of controls minus 2 SDs.
Results:
Pattern electroretinogram: P50 implicit times were delayed in 58 of 68 (85.30%) ocular hypertension eyes and 83 of 84 (98.80%) OAG eyes; P50 to N95 amplitudes were reduced in 47 (69.12%) ocular hypertension eyes and 84 (100%) OAG eyes. Visual evoked potential: P100 implicit times were delayed in 58 (85.30%) ocular hypertension eyes and 84 (100%) OAG eyes; reduced N75 to P100 amplitudes were observed in 39 (57.35%) ocular hypertension eyes and 73 (86.90%) OAG eyes. Ocular hypertension eyes showed no significant correlations (Pearson test, P>0.01) between electrophysiological parameters and age, IOP before or under medical treatment, HFA, and corneal thickness values. Significant correlations (P<0.01) were observed in OAG eyes between electrophysiological results and HFA values. Pattern electroretinogram and VEP responses were normal in all control eyes.
Conclusions:
Combined PERG/VEP recordings identified a large percentage of ocular hypertension eyes with impairment of the innermost retinal layers, notwithstanding normal optic disc morphology and normal HFA. In OAG eyes, PERG P50 to N95 amplitude and VEP P100 implicit time showed the highest sensitivity/specificity for the detection of a visual dysfunction. The presence of abnormal PERG and/or VEP responses did not allow a clearcut separation between ocular hypertension and OAG eyes.
