Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

High-speed microfluidic differential manometer for cellular-scale hydrodynamics.

Manouk Abkarian¹, Magalie Faivre, Howard A Stone

¹Division of Engineering and Applied Sciences, Harvard University, Pierce Hall, Cambridge, MA 02138, USA.

Proceedings of the National Academy of Sciences of the United States of America

|January 13, 2006

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Capillary bundling of microtubules by condensates.

bioRxiv : the preprint server for biology·2026

Same author

Room-Temperature Aerosol Dehydration of Green Fluorescent Protein.

Drying technology·2026

Same author

Ultrasensitive Detection of Macromolecules in Water Via Flowing Nanoparticles on a Microchip.

Nano letters·2026

Same author

Soft-Lubrication Drainage and Rupture in Particle-Driven Vesicles.

Physical review letters·2026

Same author

Upper Bounds on the Colloid Separation Efficiency of Diffusiophoresis.

Langmuir : the ACS journal of surfaces and colloids·2026

Same author

The influence of electrical charge on plasmodesma conductivity.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026

See all related articles

We developed a high-speed microfluidic method to measure pressure changes in tiny channels. This technique analyzes individual cell mechanics and rupture events, offering a versatile tool for studying dynamic processes in microfluidics.

Area of Science:

Fluid dynamics
Biophysics
Microfluidics

Background:

Measuring dynamic pressure variations in microchannels is challenging.
Understanding cell membrane mechanics and rupture is crucial for various biological applications.

Purpose of the Study:

To introduce a high-speed microfluidic technique for measuring dynamic pressure-drop variations.
To demonstrate its application in analyzing individual cell mechanical properties and rupture events.

Main Methods:

Development of a high-speed microfluidic device.
Measurement of pressure drop variations across micrometer-sized channels.
Correlation of pressure changes with individual cell flow and membrane rupture.

Main Results:

Related Experiment Videos

The technique successfully measured additional pressure drops caused by individual cells.
The influence of drug-modified cell membrane properties on pressure drop was quantified.
Simultaneous recording of single hemolysis events and critical membrane rupture pressure was achieved.

Conclusions:

The proposed microfluidic approach is broadly applicable for measuring dynamic processes in micro- and nanochannels.
This method provides insights into cell mechanics and rupture under flow conditions.
The technique is scale-independent and can be adapted for diverse hydrodynamic resistance studies.