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Membrane-associated STAT3 and PY-STAT3 in the cytoplasm

Mehul Shah1, Kirit Patel, Somshuvra Mukhopadhyay

  • 1Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA.

The Journal of Biological Chemistry
|January 13, 2006
PubMed
Summary

STAT3 signaling is not exclusively cytosolic. This study reveals STAT3 associates with early endosomes, impacting interleukin-6 (IL-6) signal transduction and transcriptional activation via the endocytic pathway.

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