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Related Experiment Videos

Imaging reporter genes for cell tracking with PET and SPECT.

P D Acton1, R Zhou

  • 1Department of Radiology, Thomas Jefferson University, 796-G Main Building, 132 South 10th Street, Philadelphia, PA 19107, USA. paul.acton@jefferson.edu

The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR), [And] Section of the Society Of
|January 13, 2006
PubMed
Summary

Reporter genes enable tracking transplanted cells in conditions like Parkinson's disease using advanced imaging. This review covers reporter gene strategies for Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) imaging.

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Area of Science:

  • Regenerative Medicine
  • Medical Imaging
  • Molecular Biology

Background:

  • Cell transplantation shows promise for treating tissue damage in diseases like Parkinson's and myocardial infarction.
  • Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) are sensitive imaging techniques for tracking cellular implants.
  • Reporter genes allow visualization of transplanted cells using radioactive probes.

Purpose of the Study:

  • To review reporter gene strategies for PET and SPECT imaging of transplanted cells.
  • To compare these reporter gene systems with alternative techniques and imaging modalities.

Main Methods:

  • Stable transfection of cells with reporter genes.
  • Visualization of reporter gene expression using PET and SPECT imaging with radioactive probes.

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  • Review and comparison of various reporter gene systems and imaging modalities.

    • Main Results:

    • Reporter gene-based imaging enables repeated visualization of cell migration and function.
    • PET and SPECT imaging provide sensitive detection and tracking of cellular implants.
    • Methods are translatable to human clinical applications.

    Conclusions:

    • Reporter gene imaging is a valuable tool for assessing cell trafficking in regenerative medicine.
    • PET and SPECT offer powerful, non-invasive methods for monitoring cell-based therapies.
    • This approach facilitates the evaluation of cell therapy efficacy and safety.