Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Assignment of protein function in the postgenomic era.

Alan Saghatelian1, Benjamin F Cravatt

  • 1The Skaggs Institute for Chemical Biology and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Nature Chemical Biology
|January 13, 2006
PubMed
Summary

Genome sequencing yields vast data, but understanding protein functions requires new

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DICER-driven regulation of lipid metabolism and macrophage-adipocyte crosstalk in partial lipodystrophy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Microproteins at the Frontiers of Biology and Medicine.

Annual review of cell and developmental biology·2026
Same author

Microprotein-Derived Secreted Peptide That Stimulates Cellular cAMP Production.

Biochemistry·2026
Same author

Translon: a single term for translated regions.

Nature methods·2025
Same author

Abnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice.

Science advances·2025
Same author

CRISPR-Cas9 screening reveals microproteins regulating adipocyte proliferation and lipid metabolism.

Proceedings of the National Academy of Sciences of the United States of America·2025

Area of Science:

  • Genomics
  • Proteomics
  • Biochemistry

Background:

  • Genome sequencing projects provide extensive molecular data, advancing biological understanding and disease treatment.
  • However, genome sequences alone offer limited insight into cellular biochemical pathways.
  • Proteins are central to metabolic and signaling networks, yet many remain uncharacterized.

Purpose of the Study:

  • To address the knowledge gap in cellular biochemistry.
  • To introduce and highlight novel 'postgenomic' methods for protein function assignment.

Main Methods:

  • Integration of chemical and biological techniques.
  • Application of 'postgenomic' strategies for functional proteomics.

Main Results:

  • Demonstration of new methods for assigning functions to uncharacterized proteins.
  • Highlighting the power of integrated approaches in postgenomic research.

Conclusions:

  • The study emphasizes the need for advanced methods beyond genomics.
  • Integrated chemical and biological techniques are crucial for deciphering protein functions and cellular biochemistry.

Related Experiment Videos