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Reversible photoregulation of helical structures in short peptides under indoor lighting/dark conditions
Kazuhisa Fujimoto1, Miwo Amano, Yohei Horibe
1Faculty of Pharmaceutical Sciences, University of Toyama, Japan. fujimoto@ms.toyama-mpu.ac.jp
Abstract:
[reaction: see text] A photochromic cross-linking agent with a spiropyran skeleton was developed for the reversible photoregulation of helical structures in short peptides. The helical contents of the cross-linked peptides could be regulated by ambient light and dark conditions at room temperature. This switching of the helical contents could be repeated several times without substantial loss of any activity.
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