Related Experiment Video
Updated: Jul 5, 2026

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells
Published on: August 1, 2013
The rotavirus vaccine saga
1Vaxinnate, Cranbury, New Jersey 08512, USA. ashaw@vaxinnate.com
Abstract:
Rotavirus is the single most common cause of acute, dehydrating gastroenteritis worldwide. This is a highly contagious and highly democratic disease. The attack rate in infants and young children is similar regardless of sanitation, socioeconomics or geography. Rotavirus vaccine development began in the early 1980s using a "Jennerian" approach based on rotaviruses that normally infect animals. Although these vaccines were found to be generally safe, protection from disease was inconsistent. The second generation of vaccines was based on the same animal viruses configured to carry the relevant coat proteins of human rotaviruses. An attenuated human rotavirus vaccine has also been developed. After close to 20 years of laboratory and clinical studies, safe and effective rotavirus vaccines are approaching regulatory approval.
Related Concept Videos
Vaccinations
Vaccine Production
Vaccines
Bacterial Gastroenteritis
Poliomyelitis
Respiratory Syncytial Virus Disease

