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Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells
Published on: August 1, 2013
The rotavirus vaccine saga
1Vaxinnate, Cranbury, New Jersey 08512, USA. ashaw@vaxinnate.com
Annual Review of Medicine
|January 18, 2006
Summary
Rotavirus, a common cause of gastroenteritis in children, is being targeted by new vaccines. After decades of research, safe and effective rotavirus vaccines are nearing approval for widespread use.
Area of Science:
- Pediatrics
- Vaccinology
- Infectious Diseases
Background:
- Rotavirus is the leading global cause of acute, dehydrating gastroenteritis in infants and young children.
- The disease's high contagiousness and universal impact across diverse socioeconomic and geographic settings underscore the need for effective interventions.
Purpose of the Study:
- To review the development of rotavirus vaccines.
- To highlight progress toward safe and effective rotavirus vaccines approaching regulatory approval.
Main Methods:
- Historical review of rotavirus vaccine development strategies.
- Examination of early "Jennerian" approaches using animal rotaviruses.
- Analysis of second-generation vaccines employing human rotavirus coat proteins on animal virus backbones.
- Inclusion of studies on attenuated human rotavirus vaccines.
Main Results:
- Initial rotavirus vaccines, while generally safe, offered inconsistent protection.
- Second-generation and attenuated human rotavirus vaccines have shown promise.
- Extensive laboratory and clinical studies have been conducted over approximately 20 years.
Conclusions:
- Safe and effective rotavirus vaccines are nearing regulatory approval.
- Continued vaccine development efforts are crucial for controlling rotavirus gastroenteritis worldwide.
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