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Updated: Jun 26, 2026
14:23
Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
Cd4+Cd25+ regulatory T cells and their therapeutic potential
David A Randolph1, C Garrison Fathman
1Department of Pediatrics, Division of Neonatology, Stanford University School of Medicine, Stanford, California 94305, USA. drdrdr@stanford.edu
Annual Review of Medicine
|January 18, 2006
Summary
Regulatory T cells (Tregs), identified by CD4 and CD25 markers, are crucial for controlling immune responses and preventing autoimmunity. Their therapeutic potential in modulating immune diseases is a key area of research.
Area of Science:
- Immunology
- Cell Biology
Background:
- The human immune system must distinguish self from non-self to prevent autoimmune diseases.
- Immune responses are tightly regulated to maintain self-tolerance.
- Dysregulation of immune responses can lead to autoimmune conditions and other immune-based diseases.
Purpose of the Study:
- To review the current understanding of regulatory T cells (Tregs).
- To discuss the role of Tregs in immune regulation and self-tolerance.
- To explore the therapeutic potential of Tregs in treating immune-based diseases.
Main Methods:
- Review of existing scientific literature on regulatory T cells.
- Analysis of cell surface markers (CD4 and CD25) for Treg identification.
- Discussion of Treg function in immune modulation.
Main Results:
- Regulatory T cells (Tregs) expressing CD4 and CD25 are critical for immune homeostasis.
- Tregs actively suppress immune responses against self-antigens, preventing autoimmunity.
- The function of Tregs is essential for maintaining a balanced immune system.
Conclusions:
- Regulatory T cells are key players in preventing autoimmune diseases.
- Understanding Tregs offers significant therapeutic opportunities for immune-mediated disorders.
- Targeting Tregs may provide novel treatment strategies for various human diseases.
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