Ivermectin: pharmacology and application in dermatology

Area of Science:

• Pharmacology
• Parasitology
• Dermatology

Background:

• Ivermectin is a synthetic derivative of avermectins.
• It functions as a macrolide endectocide.
• It exhibits broad-spectrum antiparasitic activity.

Purpose of the Study:

• To review the antiparasitic properties of ivermectin.
• To highlight its efficacy against endoparasites and ectoparasites.
• To discuss its therapeutic potential in various parasitic infections.

Main Methods:

• Literature review of ivermectin's pharmacological and clinical data.
• Analysis of studies detailing its mechanism of action.
• Synthesis of information on its application in treating parasitic diseases.

Main Results:

• Ivermectin demonstrates activity against numerous endoparasites (e.g., Strongyloides stercoralis, filarial worms) and ectoparasites (e.g., Sarcoptes scabies, Pediculus humanus).
• It is effective in treating cutaneous manifestations of parasitic infections.
• Its broad spectrum supports its use in diverse clinical scenarios.

Conclusions:

• Ivermectin is a valuable antiparasitic agent.
• It holds significant therapeutic interest for scabies, lice, demodecidosis, larva migrans, myiasis, and filariasis.
• Further research may expand its clinical applications.