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Structural analysis of the human neuroblastoma DNA replication complex: insights into faulty proliferation

John A Sandoval1, Jay L Grosfeld, Robert J Hickey

  • 1Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Journal of Pediatric Surgery
|January 18, 2006
PubMed
Abstract

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DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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