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Updated: Aug 13, 2026

A Coregistered Ultrasound and Photoacoustic Imaging Protocol for the Transvaginal Imaging of Ovarian Lesions
Published on: March 3, 2023
Cullen's sign following ultrasound-guided transvaginal oocyte retrieval
Yaakov Bentov1, Eliahu Levitas, Tali Silberstein
1Department of Obstetrics and Gynecology, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. ybentov@bgu.ac.il
Objective:
To describe two cases of periumbilical hematoma (Cullen's sign) following ultrasound-guided transvaginal oocyte retrieval.
Design:
Case report.
Setting:
University-affiliated teaching hospital.
Patient(S):
Two patients, 34 and 32 years old, who developed Cullen's sign following ultrasound-guided transvaginal oocyte retrieval.
Intervention(S):
Workup for pancreatitis and coagulopathies. Laparoscopy was preformed in one patient.
Main Outcome Measure(S):
Resolution of the symptoms.
Result(S):
Pancreatitis, coagulopathy, and massive hemoperitoneum were ruled out. Symptoms resided within two weeks.
Conclusion(S):
The appearance of a periumbilical hematoma (Cullen's sign) following ultrasound-guided transvaginal oocyte retrieval reflects a retroperitoneal hematoma of a benign course.
