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Detection of Endotoxin in Nano-formulations Using Limulus Amoebocyte Lysate (LAL) Assays
Published on: January 30, 2019
Application of Limulus Amebocyte Lysate (LAL) test for detecting endotoxin (pyrogen) in large volume parenterals
S Baqir Naqvi1, Tariq Mirza, Dilnawaz Sheikh
1Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
Pakistan Journal of Pharmaceutical Sciences
|January 18, 2006
Abstract:
Screening of twenty five large volume parenterals including dextrose, electrolytes, mannitol, metronidazole infusions, haemodialysis solution, water for injections and distilled water for the determination of pyrogen using Limulus Amebocyte Lysate (LAL) test has been carried out. Out of different preparations only one metronidazole injection exhibited positive LAL test, which was found pyrogen free with USP rabbit pyrogen test.
